I have on occasion has to cull the odd baby that wouldn't make it or that wasn't healthy, at the pink stage. For this I just freeze them, and it literally seems to take a few minutes and they're frozen solid.
The mice which have to be culled, are then kept and fed when needed to our young corn snake.
I have a larger snake, which would take larger mice but wondered what is the best method for culling larger mice as in 1 week + in age, so that there would be no harmful effects on the snake which eats them at a later date? also, it must be a very humane way of doing this, as it pains me when i have to cull even just the smallest baby.