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Depends on your goals. If you want mice of mixed genetics and surprise babies, then yes! If you want any certainty to your litters, definitely not. I can't say what you will get, my genetic knowledge is ok, not excellent. Almost certain that your roan and piebald will carry a plethora of other genes though, so results could be almost anything. Let us know what you get.
 

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Nothing much difficult about breeding, put them together and they will do the rest. It's all about your goals. I come from an exhibition background so breeding is quite disciplined. I'm now breeding for hobby purposes and it's much more relaxed withy own preferences prioritised. What are your goals, I'm thinking maybe hobby breeding and you hope to sell surplus?
 
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